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Dr. Ulrich F Keyser

Dr. Ulrich F Keyser

Professor of Applied Physics

Fellow of Gonville and Caius College

Biological and Soft Systems,
Room 1.84, Maxwell Centre,
Cavendish Laboratory
JJ Thomson Avenue

Cambridge CB3 0HE
Office Phone: +44 (0)1223 337272


After obtaining his PhD in low-temperature quantum transport from the Leibniz University of Hannover in Germany in 2002, Dr Keyser changed his research focus to single molecule biophysics by joining the Kavli Institute of Nanoscience at Delft University of Technology as a postdoctoral researcher. After demonstrating the first direct force measurements on DNA molecules in a nanopore, he joined Leipzig University with an Emmy Noether award as a group leader in 2006. Since 2007, Dr Keyser is a faculty member at the Cavendish laboratory working on the physics of membrane transport with financial support of an ERC starting grant (2010-2015) and an ERC consolidator grant (2015-2020).

Full CV

Research Interests

My main research is focused on understanding all transport processes through membranes of both biological and technological origin. Specifically, we are interested in the physics of ions, macromolecules and particles in confined geometries at the single molecule or particle level.  We aim to exert maximum control over all parameters in the experiment using techniques such as: DNA (origami) self-assembly, optical trapping, particle tracking, fluorescence microscopy, electrophysiology, or micro-/nanofluidics.  In parallel, we are always improving and developing new measurement techniques based on a combination of single molecule approaches.

Key Publications

N. A. W. Bell and U. F. Keyser. Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores. Nature Nanotechnology, 11:645-651, 2016.

K. Misiunas, S. Pagliara, E. Lauga, J. R. Lister, and U. F. Keyser. Nondecaying hydrodynamic interactions along narrow channels. Physical Review Letters, 115:038301, 2015

S. Pagliara, C. Schwall, and U. F. Keyser.  Optimizing Diffusive Transport Through a Synthetic Membrane Channel.  Advanced Materials, 25(6):844-849, 2013.

N. A. W. Bell, C. R. Engst, M. Ablay, G. Divitini, C. Ducati, T. Liedl, and U. F. Keyser. DNA origami nanopores.  Nano Letters (published online 20.12.2011), 12(1):512-517, 2012.

N. A. W. Bell and U. F. Keyser. Specific Protein Detection using Designed DNA Carriers and Nanopores. JACS, 137(5):2035-2041, 2015.

Complete list of publications