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Dr. Sarah E Bohndiek

Dr. Sarah E Bohndiek

Reader in Biomedical Physics at the Cavendish Laboratory

Group Leader at the Cancer Research UK Cambridge Institute

Fellow of Corpus Christi College

Room 916, Rutherford Building
Cavendish Laboratory
JJ Thomson Avenue

Cambridge CB3 0HE
Office Phone: +44 (0)1223 337267

Biography:

From 2017: Reader in Biomedical Physics, Department of Physics, Cambridge, U.K.

From 2014: Group Leader, Cancer Research UK Cambridge Institute, Cambridge, U.K.

From 2013: Fellow, Corpus Christi College, Cambridge, U.K.

2013 – 2017: University Lecturer in Biological / Biomedical Physics, Cavendish Laboratory, University of Cambridge, U.K.

2011 – 2013: Postdoctoral Scholar, Molecular Imaging Program at Stanford (MIPS), Stanford University, U.S.A. (Advisor: Prof. Sam Gambhir)

2009 – 2011: Junior Research Fellow (Non-stipendiary), Corpus Christi College, Cambridge, U.K.

2008 – 2011: Postdoctoral Research Fellow, Department of Biochemistry and Cancer Research UK Cambridge Research Institute, Cambridge, U.K. (Advisor: Prof. Kevin Brindle)

2005 – 2008: PhD Radiation Physics, Department of Medical Physics and Bioengineering, University College London (UCL), London, U.K. (Advisors: Prof. Robert Speller and Prof. Gary Royle)

Research Interests

We are a highly international and multidisciplinary research team whose passion is using new technological innovations to improve our understanding of metabolic (especially redox) processes in disease. We hope to use these innovations to improve cancer patient survival, by finding routes to enable earlier cancer detection and better prognostication. The cancer models we use range from single cells in petri dishes to intact living systems, including clinical trials in human patients. Our imaging techniques use excitation wavelengths that span the electromagnetic spectrum, with a current focus on the near-infrared, and we are particularly interested in nanophotonic detection methods.

Key Publications

  1. J Joseph, K N Baumann, P Koehler, T J Zuehlsdorff, D J Cole, J Weber, S E Bohndiek* and S Hernandez-Ainsa* (2017) DNA molecular rulers resolved at depth using photoacoustic imaging. Nanoscale. 9, 16193-16199.
  2. M R Tomaszewski, I Quiros-Gonzalez, J O’Connor, O Abeyakoon, G Parker, K Williams, F Gilbert and S E Bohndiek (2017) Oxygen enhanced photoacoustic imaging reveals vascular dynamics in murine models of prostate cancer.  Theranostics. 7 (11) 2900-2915.
  3. J Joseph, M R Tomaszewski, I Quiros Gonzalez, J Weber, J Brunker and S E Bohndiek. (2017) Evaluation of precision of optoacoustic tomography for preclinical imaging of living subjects. J Nucl Med. 58 (5) 807-814.
  4. J Weber, P C Beard and S E Bohndiek. (2016) Contrast agents for molecular photoacoustic imaging. Nature Methods 13 (8) 639-650.
  5. A small animal Raman instrument for rapid, wide-area, spectroscopic imaging.  S E Bohndiek, A Wagadarikar, C L Zavaleta, D Van De Sompel, E Garai, J V Jokerst, S Yazdanfar and S S Gambhir (2013) Proc Natl Acad Sci USA 110 (30) 12408-12413.

For our publication highlights and full list see:   http://www.bohndieklab.org/publications