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Dr. Sarah E Bohndiek

Dr. Sarah E Bohndiek

University Lecturer in Biomedical Physics at the Cavendish Laboratory

Group Leader at the Cancer Research UK Cambridge Institute

Fellow of Corpus Christi College

Room 238, Bragg Building
Cavendish Laboratory
JJ Thomson Avenue

Cambridge CB3 0HE
Office Phone: +44 (0)1223 337267

Biography:

From 2014: Group Leader, Cancer Research UK Cambridge Institute, Cambridge, U.K.

From 2013: Fellow, Corpus Christi College, Cambridge, U.K.

From 2013: University Lecturer in Biological / Biomedical Physics, Cavendish Laboratory, University of Cambridge, U.K.

2011 – 2013: Postdoctoral Scholar, Molecular Imaging Program at Stanford (MIPS), Stanford University, U.S.A. (Advisor: Prof. Sam Gambhir)

2009 – 2011: Junior Research Fellow (Non-stipendiary), Corpus Christi College, Cambridge, U.K.

2008 – 2011: Postdoctoral Research Fellow, Department of Biochemistry and Cancer Research UK Cambridge Research Institute, Cambridge, U.K. (Advisor: Prof. Kevin Brindle)

2005 – 2008: PhD Radiation Physics, Department of Medical Physics and Bioengineering, University College London (UCL), London, U.K. (Advisors: Prof. Robert Speller and Prof. Gary Royle)

Research Interests

My laboratory is a small, highly interactive and international research team whose passion is using new technological innovations to improve our understanding of metabolic (especially redox) processes in disease. We hope to use these innovations to improve cancer patient survival, by finding routes to overcome drug resistance and eventually enabling earlier cancer detection. The cancer models we use range from single cells in petri dishes to intact living systems. Our imaging techniques use excitation wavelengths that span the electromagnetic spectrum, with a current focus on the near-infrared, and we are particularly interested in nanophotonic detection methods.

Key Publications

A small animal Raman instrument for rapid, wide-area, spectroscopic imaging.  S E Bohndiek, A Wagadarikar, C L Zavaleta, D Van De Sompel, E Garai, J V Jokerst, S Yazdanfar and S S Gambhir (2013) Proc Natl Acad Sci USA 110 (30) 12408-12413.

 Molecular photoacoustic imaging of follicular thyroid carcinoma.  J Levi, S R Kothapalli, S E Bohndiek, J K Yoon, A Dragulescu-Andrasi, C Nielsen, A Tisma, S Bodapati, G Gowrishankar, X Yan, C T Chan, D Starcevic and S S Gambhir (2013) Clin Cancer Res 19 (6) 1-9.

Hyperpolarized 13C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.  S E Bohndiek, M I Kettunen, D Hu and K M Brindle (2012) Cancer Res 72 854-864.

Hyperpolarized [1-13C]-Ascorbic and Dehydroascorbic Acid: Vitamin C as a probe for imaging redox status in vivo.  S E Bohndiek, M I Kettunen, D Hu, B W C Kennedy, J Boren, F A Gallagher and K M Brindle (2011) J Am Chem Soc A 133 (30) 11795-11801.

 Comparison of methods for estimating the conversion gain of CMOS Active Pixel Sensors.  S E Bohndiek, A Blue, A T Clark, M L Prydderch, R Turchetta, G J Royle and R D Speller (2008) IEEE Sensors10 1734-1744.

A CMOS Active Pixel Sensor system for laboratory-based x-ray diffraction of biological tissue.  S E Bohndiek, E J Cook, C D Arvanitis, A Olivo, G J Royle, A T Clark, M L Prydderch, R Turchetta and R D Speller (2008)  Phys Med Biol 53 655-672.

Empirical electro-optical and x-ray performance evaluation of CMOS Active Pixel Sensors for low dose, high resolution x-ray medical imaging.  C D Arvanitis, S E Bohndiek, G J Royle, A Blue, H X Liang, A Clark, M Prydderch, R Turchetta, R D Speller (2007)  Med Phys .

For more summary details of these papers see:   http://www.bohndieklab.org/publications